Four pivotal ages in your brain’s development revealed in new scientific study


james gallagherHealth and Science Correspondent

grey placeholderMonty Rakusen/Getty Female doctor looking at MRI scanner monitor Monty Rakusen/Getty

Scientists have revealed that the brain goes through five distinct stages in life, with turning points occurring at the ages of nine, 32, 66 and 83.

The brains of nearly 4,000 people up to the age of 90 were scanned to reveal connections between cells.

Researchers at the University of Cambridge showed that the brain remains in adolescence until our early thirties when we are at “peak.”

They say the results may help us understand why the risk of mental health disorders and dementia varies across the lifespan.

The brain is constantly changing in response to new knowledge and experience – but research shows this is not a seamless pattern from birth to death.

Instead, there are these five brain stages:

  • Childhood – from birth to nine years
  • Adolescence – nine to 32 years
  • Adulthood – 32 to 66 years
  • Early aging – 66 to 83 years
  • Late old age – beyond 83 years

Dr Alexa Mousley, lead author of the research, told the BBC: “The brain continues to rewire throughout life. It’s always strengthening and weakening connections and it’s not a stable pattern – there are ups and downs and phases of brain rewiring.”

Some people will reach these milestones earlier or later than others – but the researchers said it was surprising how clearly these ages stood out in the data.

These patterns have now emerged thanks to the amount of brain scans available in the study, which was published in the journal Nature Communications.

five brain stages

Childhood -The first period is when the size of the brain is increasing rapidly, but at the same time the abundance of connections between brain cells formed early in life, called synapses, is also decreasing.

In this state the brain becomes less efficient. It works like a child running around the park, going wherever he likes instead of going straight from A to B.

adolescence – This changes suddenly from the age of nine when the connections in the brain go through a period of brutal efficiency. “This is a huge change,” Dr. Moussali said, describing the brain’s most profound change between stages.

This is the time when there is the greatest risk for the onset of mental health disorders.

It’s no surprise that adolescence begins around the beginning of puberty, but this is the latest evidence that it ends much later than we thought. It was once thought to be limited to adolescence, before neuroscience suggested it continues into your 20s and now into your early 30s.

This stage is the only stage in the brain when the network of neurons becomes more efficient. Dr Moussali said this is supported by multiple measurements of brain function, which show that it peaks in your early thirties, but it is “very interesting” that the brain remains in the same stage between nine and 32.

adulthood -This is followed by a period of stability for the brain as it enters its longest era, lasting three decades.

The change during this period is slower than in earlier fireworks, but here we see that the improvements in brain function have been reversed.

Dr. Mousley said this “aligns with the plateauing of intelligence and personality” that many of us may have seen or experienced.

early aging – It starts at 66, but it is not a sudden and sudden decline. Instead there are changes in the patterns of connections in the brain.

Instead of being coordinated as a whole brain, the organ becomes increasingly divided into areas that work tightly together – like band members starting their solo projects.

Although the study focused on healthy brains, this is also the age when dementia and high blood pressure, which affect brain health, are starting to appear.

late aging – Then at the age of 83 we enter the final stage. There is less data than other groups because it was more challenging to find healthy brains to scan. Changes in the brain are similar to those of early aging, but even more pronounced.

Dr. Moussali said what really surprised him was that different “ages coincide with many important milestones” such as puberty, health concerns later in life, and even big social transitions like becoming a parent in your early 30s.

‘Excellent study’

The study did not look at men and women separately, but there will be questions such as the effects of menopause.

Duncan Astle, Professor of Neuroinformatics at the University of Cambridge and member of the team responsible for the research, said: “Many neurodevelopmental, mental health and neurological conditions are linked to brain wiring. Indeed, differences in brain wiring predict difficulties with attention, language, memory and a whole range of different behaviours.”

Professor Tara Spiers-Jones, director of the Center for Discovery Brain Sciences at the University of Edinburgh, who did not work on the paper, said: “This is a really great study that highlights how much our brain changes over our lifetime.”

He said the results “fit in perfectly” with our understanding of brain aging, but cautioned that “not everyone will experience these network changes at the same age”.



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